Emerging challenges in critical domains were the key focus of the recent Comprehensive Security Cooperation (CSC25-1) course hosted by the Daniel K. Inouye Asia-Pacific Center for Security Studies from February 5 to March 12, 2025, in Honolulu. The intensive five-week course helped build capacity for allies and partners by leveraging the different perspectives, skills, and experiences of its multinational Fellows, which included 89 participants from 35 countries around the world. CSC 25-1 focused on critical security domains—Cyber, Space, and Maritime Security—providing Fellows with strategic insights into emerging challenges and opportunities. Through plenary sessions, scenario-based exercises, simulations, and specialized electives, the course fosters collaboration and strengthens the capacity of security practitioners to address complex security threats.